Characterization of a quaternary-structured folding intermediate of an antibody Fab-fragment
نویسندگان
چکیده
منابع مشابه
alpha-lytic protease precursor: characterization of a structured folding intermediate.
The bacterial alpha-lytic protease (alphaLP) is synthesized as a precursor containing a large N-terminal pro region (Pro) transiently required for correct folding of the protease [Silen, J. L., and Agard, D. A. (1989) Nature 341, 462-464]. Upon folding, the precursor is autocatalyticly cleaved to yield a tight-binding inhibitory complex of the pro region and the fully folded protease (Pro/alpha...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2008
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560040511